Chronic Leukemias
Long-term management of chronic lymphocytic and chronic myeloid leukemias.
Overview
Chronic leukemias — including chronic lymphocytic leukemia (CLL) and chronic myeloid leukemia (CML) — are slow-growing blood cancers that often require long-term management rather than aggressive upfront treatment.
CML has been transformed by tyrosine kinase inhibitors, and CLL treatment has been revolutionized by BTK inhibitors and BCL-2 inhibitors. Our hematologists are experienced in selecting the right therapy and monitoring for optimal long-term outcomes.
Symptoms & Warning Signs
- Persistent fatigue
- Swollen lymph nodes
- Frequent infections
- Easy bruising or bleeding
- Unexplained weight loss
- Night sweats
Diagnosis & Evaluation
Blood Work
CBC, peripheral smear, flow cytometry
Molecular Testing
BCR-ABL for CML; IGHV, TP53, del(17p) for CLL
Bone Marrow Biopsy
For staging and classification
Treatment Options
Frequently Asked Questions
Does chronic leukemia always need treatment?
Not always. Many CLL patients are monitored with a 'watch and wait' approach until treatment criteria are met. CML typically requires treatment at diagnosis with a TKI.
Can CML be cured?
While most CML patients take TKI therapy long-term, some patients who achieve deep molecular remission may be eligible for treatment-free remission trials.
