Myeloproliferative Disorders
Diagnosis and management of conditions where bone marrow produces too many blood cells.
Overview
Myeloproliferative neoplasms (MPNs) are a group of blood disorders in which the bone marrow overproduces red blood cells, white blood cells, or platelets. Conditions include polycythemia vera, essential thrombocythemia, and myelofibrosis.
Our hematologists have extensive experience managing these chronic conditions, using targeted therapies like JAK inhibitors alongside careful monitoring to reduce complications and maintain quality of life.
Symptoms & Warning Signs
- Fatigue and weakness
- Headaches or dizziness
- Enlarged spleen (abdominal fullness)
- Night sweats
- Itching, especially after bathing
- Blood clots or unusual bleeding
Diagnosis & Evaluation
Blood Work
CBC with differential, peripheral smear
Molecular Testing
JAK2, CALR, and MPL mutation analysis
Bone Marrow Biopsy
Reticulin and collagen fibrosis assessment
Treatment Options
Frequently Asked Questions
Are MPNs a type of cancer?
MPNs are classified as blood neoplasms (cancers), but many behave as chronic conditions that can be managed for years with appropriate treatment.
Can MPNs transform into leukemia?
There is a small risk of transformation to acute myeloid leukemia over time. Regular monitoring helps detect any changes early.
